Jun Hwi Cho
Kangwon National University, Republic of Korea
Title: Effects of regional body temperature during asphyxial cardiac arrest on mortality and brain damage in rats
Biography
Biography: Jun Hwi Cho
Abstract
Purpose: To date, hypothermia has focused on improving rates of resuscitation to increase survival rates in cardiac arrest (CA) patients. For this, it needs to understand what body temperature affects neuronal damage/death in the brain during CA. However, few studies on effects of regional temperature in the body during CA on survival rate and neurological outcomes have been studied.
Materials and methods: Here, we used adult male rats (12 week-old) which were subjected to 4 conditions as follows: (i) whole body normothermia (37±0.5°C) plus (+) no asphyxial CA, (ii) whole body normothermia+CA, (iii) whole body hypothermia (33±0.5°C)+CA, (iv) body hypothermia/brain normothermia+CA, and (v) brain hypothermia/body normothermia+CA.
Results: Survival rate after resuscitation was significantly high in groups of whole body hypothermia+CA and body hypothermia/brain normothermia+CA, but not in groups of whole body normothermia+CA and brain hypothermia/body normothermia+CA. However, the group of hypothermia/brain normothermia+CA exhibited higher neuroprotective effect against asphyxial CA injury: neurological deficit and neuronal death in the hippocampus were improved compared to those in the group of whole body normothermia+CA. In addition, neurological deficit and neuronal death in the group of brain hypothermia/body normothermia+CA were was similar to those in the group of whole body normothermia+CA.
Conclusions: In brief, only brain hypothermia during CA did not show effective survival rate, neurological function and neuronal protection compared to those under body (not brain) hypothermia during CA. Our present study suggests that regional temperature in patients during CA can significantly affect outcomes in survival rate and neurological recovery.