Allal Boutajangout graduated from Free University of Brussels (ULB-Erasme Hospital), School of Medicine (PhD in Neuropathology). He completed his Postdoctoral training at New York University School of Medicine. He is a Research Associate Professor of Neurology and Neuroscience & Physiology and Psychiatry. He is also the chief of Neurodegeneration and Drug Discovery Program within Center for Cognitive Neurology at NYU. He received prestigious award Margaret M Cahn for his outstanding research in the field of Alzheimer’s and other awards from: Alzheimer association, NIH pilot grant, Toyama Company, Revalesio Company and coinvestigator in 5 RO1 NIH grants. He has published more than 30 papers in reputed journals and serves as a reviewer for many scientific journals.
Background: Immunotherapy is emerging as promising approach to treat Alzheimer’s disease. We have previously shown that prophylactic active and passive immunization clears tau aggregates from different area of the brain and prevent mproves cognitive decline. Here we assessed if our new monoclonal antibody against PHF-Tau would be efficacious in tangles model of Alzheimer’s disease. Methods: Homozygous P301L mice (2-2.5 months of age) were injected intraperitoneally one per eek with our new monoclonal antibody 11B7 and controls received PBS only (200ug/125 μl; n=10 per group) for a total of 13 injections. Results: Treated animals (n=10) didn’t show a significant difference on sensorimotor tasks (Traverse beam, Locomotor activity) while a significant difference was observed with the rotarod test (One tailed, t-student p=0.0489). Significant statistical differences were observed with the novel object recognition test (75% time spent with a novel objects (One tailed, t-student p=0.0004) 25% for controls (One tailed, t-student P>0.05), and with the closed field symmetrical maze (Day1 one tailed, t-test P=0.0001; Day2 one tailed t-student P=0001; Day3 one tailed t test P=0.0003). Immunohistochemistry analysis with PHF1 and CP13 showed a reduction of tau pathology in the cortex and in the hippocampus which correlates with the behavioral results. By Western blotting, the antibody therapy reduces tau pathology in the cortex and in the hippocampus. Further analysis is underway. Conclusion: passive immunization with our new monoclonal antibody decreases tau pathology by immunotherapy, biochemistry and improves cognitive decline in P301L mice.
Fagogenis Gerasimos has done his Post-graduation from the Athens University. He did his Doctorate in Medicine. He has done his practiced in Pediatrics from the University Clinics of: Evangelismos Hospital, Athens. In the year 1979, he got License for Medical Practice in Pediatrics.
Over preliminary avocation to (virtual) experimentation upon the feasibility of regional or overall transmission of human brain’s electromagnetic waves work as an EEG signal configuration to another Person’s cerebral cortex, but remotely like a modulated signal of compatible frequency magnitude, without implement mediation e.g. microchip, cerebral implants or skull electrodes in open air and on any GPS parameter. Emission interaction from brain-to-brain (B-B Interface) means radio antennas sensors and satellite mediated procedures. Primary schedule runs as: EEG graphic waves properly detected, through specific sensitive appliances gathered to be transmitted to other participant’s brain. It follows a detectable phase difference elaboration of those EEG graphic signals because these are compatible with human brain’s electrophysiology. Here not a PC but cortex is the decoding matter. Effects are impressive and constitute cognitive communication of other’s cerebral functions thoughts includeḋ resulting in comprehension of the masa copied speech analog on parallel, coinciding technically to the long spoken concept of telepathy. That goes back even to the very early origination of mental constructions’ that is to thought and intangible (sensed) images making. Furthermore, this brain-to-brain transmission comprises not only cognitive but also sensory interpretations. The quality of perception and interaction from person to person coincides with reality in some fields while simultaneously and at any moment intangible sensory and cognitive images noetic forms Gestalt are realized bilaterally: Psychesthetism is the essence in perception and comprehension. Always, speech and interaction simulate open space conversation.